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2015/16 I-MOVE/I-MOVE+ multicentre case-control study in Europe: Moderate vaccine effectiveness estimates against influenza A(H1N1)pdm09 and low estimates against lineage-mismatched influenza B among children

Identifieur interne : 000136 ( Main/Exploration ); précédent : 000135; suivant : 000137

2015/16 I-MOVE/I-MOVE+ multicentre case-control study in Europe: Moderate vaccine effectiveness estimates against influenza A(H1N1)pdm09 and low estimates against lineage-mismatched influenza B among children

Auteurs : Esther Kissling [France] ; Marta Valenciano [France] ; Francisco Pozo [Espagne] ; Ana-Maria Vilcu [France] ; Annicka Reuss [Allemagne] ; Caterina Rizzo [Italie] ; Amparo Larrauri [Espagne] ; Judit Krisztina Horváth [Hongrie] ; Mia Brytting [Suède] ; Lisa Domegan [Irlande (pays)] ; Monika Korczy Ska [Pologne] ; Adam Meijer [Pays-Bas] ; Ausenda Machado [Portugal] ; Alina Ivanciuc [Roumanie] ; Vesna Višekruna Vu Ina [Croatie] ; Sylvie Van Der Werf [France] ; Brunhilde Schweiger [Allemagne] ; Antonino Bella [Italie] ; Alin Gherasim [Espagne] ; Annamária Ferenczi [Hongrie] ; Katherina Zakikhany [Suède] ; Joan O Onnell [Irlande (pays)] ; Iwona Paradowska-Stankiewicz [Pologne] ; Frederika Dijkstra [Pays-Bas] ; Raquel Guiomar [Portugal] ; Mihaela Lazar [Roumanie] ; Sanja Kure I Filipovi [Croatie] ; Kari Johansen [Suède] ; Alain Moren [France]

Source :

RBID : Hal:hal-02102565

English descriptors

Abstract

BACKGROUND: During the 2015/16 influenza season in Europe, the cocirculating influenza viruses were A(H1N1)pdm09 and B/Victoria, which was antigenically distinct from the B/Yamagata component in the trivalent influenza vaccine.METHODS: We used the test-negative design in a multicentre case-control study in twelve European countries to measure 2015/16 influenza vaccine effectiveness (VE) against medically attended influenza-like illness (ILI) laboratory-confirmed as influenza. General practitioners swabbed a systematic sample of consulting ILI patients and a random sample of influenza-positive swabs was sequenced. We calculated adjusted VE against influenza A(H1N1)pdm09, A(H1N1)pdm09 genetic group 6B.1 and influenza B overall and by age group.RESULTS: We included 11 430 ILI patients, of which 2272 were influenza A(H1N1)pdm09 and 2901 were influenza B cases. Overall VE against influenza A(H1N1)pdm09 was 32.9% (95% CI: 15.5-46.7). Among those aged 0-14, 15-64 and ≥65 years, VE against A(H1N1)pdm09 was 31.9% (95% CI: -32.3 to 65.0), 41.4% (95% CI: 20.5-56.7) and 13.2% (95% CI: -38.0 to 45.3), respectively. Overall VE against influenza A(H1N1)pdm09 genetic group 6B.1 was 32.8% (95% CI: -4.1 to 56.7). Among those aged 0-14, 15-64 and ≥65 years, VE against influenza B was -47.6% (95% CI: -124.9 to 3.1), 27.3% (95% CI: -4.6 to 49.4) and 9.3% (95% CI: -44.1 to 42.9), respectively.CONCLUSIONS: Vaccine effectiveness (VE) against influenza A(H1N1)pdm09 and its genetic group 6B.1 was moderate in children and adults, and low among individuals ≥65 years. Vaccine effectiveness (VE) against influenza B was low and heterogeneous among age groups. More information on effects of previous vaccination and previous infection is needed to understand the VE results against influenza B in the context of a mismatched vaccine.


Url:
DOI: 10.1111/irv.12520


Affiliations:


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<title xml:lang="en">2015/16 I-MOVE/I-MOVE+ multicentre case-control study in Europe: Moderate vaccine effectiveness estimates against influenza A(H1N1)pdm09 and low estimates against lineage-mismatched influenza B among children</title>
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<name sortKey="Kure I Filipovi, Sanja" sort="Kure I Filipovi, Sanja" uniqKey="Kure I Filipovi S" first="Sanja" last="Kure I Filipovi">Sanja Kure I Filipovi</name>
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<name sortKey="Johansen, Kari" sort="Johansen, Kari" uniqKey="Johansen K" first="Kari" last="Johansen">Kari Johansen</name>
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<orgName>European Centre for Disease Prevention and Control</orgName>
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<addrLine>Stokholm</addrLine>
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<name sortKey="Moren, Alain" sort="Moren, Alain" uniqKey="Moren A" first="Alain" last="Moren">Alain Moren</name>
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<orgName>EpiConcept [Paris]</orgName>
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<idno type="DOI">10.1111/irv.12520</idno>
<series>
<title level="j">Influenza and Other Respiratory Viruses</title>
<idno type="ISSN">1750-2640</idno>
<imprint>
<date type="datePub">2018</date>
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<keywords scheme="mix" xml:lang="en">
<term>case-control study</term>
<term>case‐control study</term>
<term>influenza</term>
<term>influenza vaccine</term>
<term>multicentre study</term>
<term>vaccine effectiveness</term>
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<div type="abstract" xml:lang="en">
<p>BACKGROUND: During the 2015/16 influenza season in Europe, the cocirculating influenza viruses were A(H1N1)pdm09 and B/Victoria, which was antigenically distinct from the B/Yamagata component in the trivalent influenza vaccine.METHODS: We used the test-negative design in a multicentre case-control study in twelve European countries to measure 2015/16 influenza vaccine effectiveness (VE) against medically attended influenza-like illness (ILI) laboratory-confirmed as influenza. General practitioners swabbed a systematic sample of consulting ILI patients and a random sample of influenza-positive swabs was sequenced. We calculated adjusted VE against influenza A(H1N1)pdm09, A(H1N1)pdm09 genetic group 6B.1 and influenza B overall and by age group.RESULTS: We included 11 430 ILI patients, of which 2272 were influenza A(H1N1)pdm09 and 2901 were influenza B cases. Overall VE against influenza A(H1N1)pdm09 was 32.9% (95% CI: 15.5-46.7). Among those aged 0-14, 15-64 and ≥65 years, VE against A(H1N1)pdm09 was 31.9% (95% CI: -32.3 to 65.0), 41.4% (95% CI: 20.5-56.7) and 13.2% (95% CI: -38.0 to 45.3), respectively. Overall VE against influenza A(H1N1)pdm09 genetic group 6B.1 was 32.8% (95% CI: -4.1 to 56.7). Among those aged 0-14, 15-64 and ≥65 years, VE against influenza B was -47.6% (95% CI: -124.9 to 3.1), 27.3% (95% CI: -4.6 to 49.4) and 9.3% (95% CI: -44.1 to 42.9), respectively.CONCLUSIONS: Vaccine effectiveness (VE) against influenza A(H1N1)pdm09 and its genetic group 6B.1 was moderate in children and adults, and low among individuals ≥65 years. Vaccine effectiveness (VE) against influenza B was low and heterogeneous among age groups. More information on effects of previous vaccination and previous infection is needed to understand the VE results against influenza B in the context of a mismatched vaccine.</p>
</div>
</front>
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<li>Espagne</li>
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